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Volume 16 (5); 2025

Research Papers

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Factors Affecting Delayed Recovery from Neutropenia in Patients with pancreatic Cancer Receiving Gemcitabine Plus Nab-Paclitaxel
Naoko Yoshida, Shungo Imai, Kazuyoshi Kawakami, Takashi Yokokawa, Masashi Nakamura, Takeshi Aoyama, Hisanori Shimizu, Ryoichi Naito, Minori Teramae, Masami Tsuchiya, Hayato Kizaki, Masato Ozaka, Naoki Sasahira, Masakazu Yamaguchi, Satoko Hori
J. Cancer 2025; 16(5): 1413-1419. doi:10.7150/jca.107359
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WTAP-Mediated N6-Methyladenosine Modification Promotes Gastric Cancer Progression by Regulating MAP2K6 Expression
Shuangshuang Han, Haibin Jiang, Jia Wang, Chao Li, Ting Liu, Mingda Xuan, Bo Tian, Yi Si, Hongyan Zhao, Yunxia Zhao, Zhenlong Zhu, Weifang Yu, Lihong Wang
J. Cancer 2025; 16(5): 1420-1437. doi:10.7150/jca.98559
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Single-Cell Sequencing Reveals PD-L1-Mediated Immune Escape Signaling in Lung Adenocarcinoma
Anbing Zhang, Jianping Liang, Xiaoli Lao, Xiuqiong Xia, Siqi Li, Shengming Liu
J. Cancer 2025; 16(5): 1438-1450. doi:10.7150/jca.103656
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Integrative Predictive Nomograms for Treatment Decision-Making in Resectable Synchronous Colorectal Liver Metastases
Yujuan Jiang, Dedi Jiang, Jinghua Chen, Heting Feng, Zixing Zhu, Jun Jiang, Fan Wu, Jianwei Liang
J. Cancer 2025; 16(5): 1451-1465. doi:10.7150/jca.107194
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Tumor cell-derived hyaluronan fragments induce endocytosis of S1PR1 to promote lymphangiogenesis through LYVE-1-Src pathway
Mengying Jiang, Dandan Chen, Zhangrun Xu, Yiwen Liu, Cuixia Yang, Guoliang Zhang, Qian Guo, Feng Gao, Yiqing He, Yan Du
J. Cancer 2025; 16(5): 1466-1478. doi:10.7150/jca.104309
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Integrative multi-omics and machine learning identify a robust signature for discriminating prognosis and therapeutic targets in bladder cancer
Zhiyong Tan, Xiaorong Chen, Yinglong Huang, Shi Fu, Haihao Li, Chen Gong, Dihao Lv, Chadanfeng Yang, Jiansong Wang, Mingxia Ding, Haifeng Wang
J. Cancer 2025; 16(5): 1479-1503. doi:10.7150/jca.105066
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LncRNA C2orf27A Promotes Gastric Cancer by Sponging MiR-610 and Elevating NOX4 Expression
Mingkai Zhuang, Xiaoxiong Guo, Dan Lin, Na Lin, Xiaozhong Wang, Fenglin Chen
J. Cancer 2025; 16(5): 1504-1518. doi:10.7150/jca.100621
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The Role of MATN3 in Cancer Prognosis and Immune Infiltration Across Multiple Tumor Types
Chongjiu Qin, Haifei Qin, Haixiang Xie, Yuhua Li, Aoyang Bi, Xiwen Liao, Kejian Yang, Chunmiao Lu, Tao Peng, Guangzhi Zhu
J. Cancer 2025; 16(5): 1519-1537. doi:10.7150/jca.103523
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Overexpression of MCM3 as a prognostic biomarker correlated with cell proliferation, cell cycle and immune regulation in hepatocellular carcinoma
Linling Ju, Huixuan Wang, Yunfeng Luo, Yichen Wang, Lin Chen, Xudong Han, Rujian Lu
J. Cancer 2025; 16(5): 1538-1554. doi:10.7150/jca.104325
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Propofol reduces breast cancer cell stemness via FOXO3/SOX2 axis
Wen-Qian Fang, Xiao-Bei Zhang, Yue Yu, Jie Ge, Ran Meng
J. Cancer 2025; 16(5): 1555-1562. doi:10.7150/jca.104142
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Incidence and survival patterns of clear cell renal cell carcinoma from 2000 to 2017: A SEER Database Analysis
Sijue Zou, Liwen Cui, Pearl Pai, Yiping Lu, XiangYang Li, Gang Wang, Wen Huang, Dan Wang, Nikhat Shaikh, Zhangzhe Peng, Zhuoming Peng, Haiyan He, Zhouning Liao
J. Cancer 2025; 16(5): 1591-1597. doi:10.7150/jca.105713
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The mutualistic relationship between M2c macrophages of TGFβ1 induction and gastric cancer cells: the correlation between protective mechanisms in the tumor microenvironment and polarization of subtypes of cells
Kaiqiang Meng, Jian Song, Fan Qi, Jiamin Li, Zhichao Fang, Liang Song, Shaonan Shi
J. Cancer 2025; 16(5): 1598-1617. doi:10.7150/jca.97784
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Stigmasterol Attenuates Triple-negative Breast Cancer Stem Cell Properties by Inhibiting JAK3
Ruijuan Zhou, Yuzhu Zhang, Leqin Xu, Yang Sun
J. Cancer 2025; 16(5): 1618-1630. doi:10.7150/jca.94822
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CRABP2 (Cellular Retinoic Acid Binding Protein 2D): A novel biomarker for the diagnosis and prognosis involved in immune infiltration of lung adenocarcinoma
Daxia Cai, Feng Tian, Dengke Zhang, Jianfei Tu, Yonghui Wang
J. Cancer 2025; 16(5): 1631-1646. doi:10.7150/jca.96518
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LINC00899 suppresses the progression of triple-negative breast cancer via the miRNA-425/PTEN axis and is a biomarker for neoadjuvant chemotherapy efficacy
Lianjie Niu, Yongtao Bai, Meng Yu, Xianfu Sun
J. Cancer 2025; 16(5): 1647-1655. doi:10.7150/jca.100619
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Prognostic Significance of CDK1 in Ovarian and Cervical Cancers
Cong Xu, Chaowen Chen, Yonghong Xu, Zhenqi Li, Huaqiu Chen, Guangming Wang
J. Cancer 2025; 16(5): 1656-1667. doi:10.7150/jca.104371
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Identification of a Lactate Accumulation Model to Explain the Heterogeneity in Prognosis, Immune Landscape, and Tumor Environment for HNSCC patients
Yi Jin, Xiang Xiao, Jiayu Xiang, Tingjie Yu, Tingting Wang, Yonghong Zhou, Siwei Huang
J. Cancer 2025; 16(5): 1668-1683. doi:10.7150/jca.99560
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NUPR1 contributes to endocrine therapy resistance by modulating BIRC5 expression and inducing luminal B-ERBB2+ subtype-like characteristics in estrogen receptor-positive breast cancer cells
Chun-Hui Lee, Yi-Chen Lin, Yung-Chieh Chang, Pin-Chen Chen, Kai-Hsuan Lin, Tzu-Miao Yeh, Euphemia Yee Leung, I-Li Lin, Shang-Hung Chen, Chun Hei Antonio Cheung
J. Cancer 2025; 16(5): 1694-1708. doi:10.7150/jca.105425
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KLK7 Involvement in Thyroid Papillary Carcinoma Cell Migration and Invasion by EMT via MAPK/ERK Pathways
Min Li, Zi-Wen Li, Jia-Yin Song, Yu Bin, Tao Ni, Gang Xue, Xu Lin, Jing-Fang Wu
J. Cancer 2025; 16(5): 1709-1725. doi:10.7150/jca.101555
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Addition of Bevacizumab to Vinorelbine-Platinum combination is efficacious in Heavily Pretreated HER2-Negative Metastatic Breast Cancer
I-Wei Ho, Yi-Ru Tseng, Chun-Yu Liu, Yi-Fang Tsai, Chi-Cheng Huang, Ling-Ming Tseng, Ta-Chung Chao, Jiun-I Lai
J. Cancer 2025; 16(5): 1726-1735. doi:10.7150/jca.105199
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ADAM10 is a key player in the diagnosis, prognosis and metastasis of non-small cell lung cancer (NSCLC)
Wenqian Zhang, Liyao Yang, Mufan Li, Lianmei Zhang, Jingliang Cheng, Ali H. El-Far, Youhua Xu, Junjiang Fu
J. Cancer 2025; 16(5): 1736-1746. doi:10.7150/jca.107236
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The Impact of MET Variants in Oral Cancer Progression and Clinicopathological Characteristics
Ping-Ju Chen, Yen-Ting Lu, Wei-En Yang, Chun-Wen Su, Lun-Ching Chang, Shun-Fa Yang, Chiao-Wen Lin, Ying-Erh Chou
J. Cancer 2025; 16(5): 1747-1753. doi:10.7150/jca.106426
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Reviews

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Intercellular Adhesion Molecule 3: Structure, Cellular Functions, and Emerging Role in Human Diseases
Xinzhuang Shen, Dehong Luo, Xiaowen Yang, Yifei Li, Fuming Lian, Huan Liu, Xiaoyuan Zhang, Wenzhi Shen
J. Cancer 2025; 16(5): 1563-1574. doi:10.7150/jca.100612
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Molecular insight into histone methylation as a novel target for oral squamous cell carcinoma: future hope in personalised medicine
Peramaiyan Rajendran, Monisha Prasad, Enas M Ali, Ramya Sekar, Abdullah M AlZahrani, Mohmed Isaqali Karobari, Marwa Azmy M. Genena, Basem M Abdallah
J. Cancer 2025; 16(5): 1575-1590. doi:10.7150/jca.103243
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Malignant Transformation of Meningiomas
Jinxiu Yu, Jiaojiao Deng, Leihao Ren, Lingyang Hua, Ye Gong
J. Cancer 2025; 16(5): 1684-1693. doi:10.7150/jca.105024
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