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Volume 16 (6); 2025

Research Papers

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Characterization of lncRNA-Driven Networks in Portal Vein Tumor Thrombosis: Implications for Hepatocellular Carcinoma Progression
Ji Young Kim, So Hee Dho, Lark Kyun Kim
J. Cancer 2025; 16(6): 1754-1767. doi:10.7150/jca.107270
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System Analysis Identifies MYBL2 As a Novel Oncogene Target for Metastatic Prostate Cancer
Renlun Huang, Jing Li, Jiawei Zhu, Wei Deng, Zhichao Wang, Songtao Xiang
J. Cancer 2025; 16(6): 1768-1781. doi:10.7150/jca.107232
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Multi-omics analysis reveals lysosome-associated molecular subtype characterization and prognostic modeling system in lung adenocarcinoma
Zhanmei Wang, Yan Wang, Jinxiang Wang
J. Cancer 2025; 16(6): 1794-1813. doi:10.7150/jca.105351
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Identification of GPX3 and JUN as Tumor Suppressors in Thyroid Cancer through Integrated WGCNA and Mendelian Randomization
Renjie Zhang, Yutao Chen, Sha Xu, Xue Gu, Hui Ye
J. Cancer 2025; 16(6): 1814-1831. doi:10.7150/jca.104687
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Both consolidation and maintenance treatment improve outcomes in primary central nervous system lymphoma: real-world evidence from a tertiary medical center
Chieh-Lung Cheng, Chang-Tsu Yuan, Wei-Quan Fang, Po-Hao Huang, Hsin-An Hou, Cheng-Hong Tsai, Ming Yao, Wen-Chien Chou, Hwei-Fang Tien
J. Cancer 2025; 16(6): 1836-1847. doi:10.7150/jca.107661
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Exploring The Causal Relationship Between Lipid Profiles and Colorectal Cancer Through Mendelian Randomization: A Multidimensional Plasma Lipid Composition Perspective
Hailan Wu, Jialin Gu, Yun He, Yi Ji, Wen Cao, Rongrong Li, Zhancheng Gu, Guoli Wei, Jiege Huo
J. Cancer 2025; 16(6): 1848-1859. doi:10.7150/jca.103247
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Multi-Omics Profiling Identifies a High-Risk Subgroup of Breast Cancer Stem Cells for Prognostic Stratification and Personalized Treatment
Guixin Wang, Ziyi Chen, Yao Tian, Yuxin Zhu, Shuo Wang, Wenbin Song, Xin Wang, Yingxi Li
J. Cancer 2025; 16(6): 1860-1872. doi:10.7150/jca.109589
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Identification of M2 macrophage markers for predicting outcome and therapeutic response in osteosarcoma: Integrated analysis of single-cell and bulk RNA-sequencing
Yang Liu, Liwei Liu, Xianpeng Wei, Yan Xiong, Qifang Han, Tianhui Gong, Fuzhou Tang, Kaide Xia, Shuguang Zheng
J. Cancer 2025; 16(6): 1873-1887. doi:10.7150/jca.104855
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RNF114 Interacts with EWSR1 to Regulate VEGFR2 in HER2-positive Breast Cancer
Yingchuan Zhu, Yue Song, Yilu Lu, Wenhao Jiang, Jingfei Zhang, Lan Yin, Xinyu Lin, Dachang Tao, Yongxin Ma
J. Cancer 2025; 16(6): 1888-1904. doi:10.7150/jca.106001
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Mitoxantrone-liposome Sensitizes FLT3-ITD Acute Myeloid Leukemia to Gilteritinib Treatment
Shiyi Yuan, Ying Zhou, Yifei Li, Zhe Chen, Wenrui Xiao, Danqing Jiang, Ping Zhang, Ying Zhang, Fengxia Bai, Jianchuan Deng, Shifeng Lou
J. Cancer 2025; 16(6): 1905-1917. doi:10.7150/jca.105557
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Deciphering the Role of CD14 in Helicobacter Pylori-associated Gastritis and Gastric Cancer: Combing Bioinformatics Analysis and Experiments
Xuefei Yang, Jiaqi Zhang, Ping Wang, Fengyun Wang, Xudong Tang
J. Cancer 2025; 16(6): 1918-1933. doi:10.7150/jca.106847
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EIF4A3 Promotes Cell Proliferation via CDC5L Upregulation in Human Breast Cancer Cells
Miao Zhang, Yuchen Xie, Shaoran Song, Ruiqi Wang, He Chen, Yazhao Li, Jie Liu, Juan Li, Yina Jiang, Peijun Liu, Bo Wang
J. Cancer 2025; 16(6): 1958-1970. doi:10.7150/jca.108895
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Clinical significance and immune landscape analyses of the coagulation-related gene signatures in gastric cancer
Yueming Yu, Dingwei Liu, Jun Xie, Zhou Feng, Xiaoping Huang, Hui Li, Yong Xie, Xiaojiang Zhou
J. Cancer 2025; 16(6): 1971-1986. doi:10.7150/jca.104221
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CKS2 Silencing Affects Proliferation and Apoptosis in Multiple Myeloma through the PTEN/ AKT/mTOR Pathway
Jing Zi-zi, Yu Wei, Tang Jia-lin, Zhou Xiao-bin, Chen Jian-bin
J. Cancer 2025; 16(6): 1987-2000. doi:10.7150/jca.106190
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A machine learning model utilizing CT radiomics features and peripheral blood inflammatory markers predicts the prognosis of patients with unresectable esophageal squamous cell carcinoma undergoing PD-1 inhibitor combined with concurrent chemoradiotherapy
Xudong Liu, Fei Gao, Shusheng Wu, Haoyu Wang, Wenxi Dang, Mingjie Sun, Zhihua Zhang, Mengge Li, Zhirun Cai, Wen Li, Yifu He
J. Cancer 2025; 16(6): 2001-2014. doi:10.7150/jca.105171
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CCL4 and MIF: Prognostic Biomarkers for Evaluating the Chemoradiotherapy Response and Prognosis in Patients with ESCC
Yuwen Wang, Chunxue Ding, Xiaoying Wei, Yuting Li, Xuyao Yu, Xi Chen, Jifeng Sun, Junhong Zhuang, Shuai Cao, Peng Zhen, Fang Fang, Jiarui Zhang, Jun Wang, Dong Qian, Qingsong Pang
J. Cancer 2025; 16(6): 2015-2025. doi:10.7150/jca.104088
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Identification of hub genes for the diagnosis and prognosis in triple negative breast cancer using transcriptome and differential methylation integration analysis
Baoe Liu, Xiaoli Yang, Huxia Wang, Peijun Liu, Qing Feng, Cuixiang Xu, Zhangjun Song
J. Cancer 2025; 16(6): 2026-2040. doi:10.7150/jca.104472
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Development and validation of an explainable machine learning model to predict Delphian lymph node metastasis in papillary thyroid cancer: a large cohort study
Jie Cui, Genglong Liu, Kai Yue, Yansheng Wu, Yuansheng Duan, Minghui Wei, Xudong Wang
J. Cancer 2025; 16(6): 2041-2061. doi:10.7150/jca.110141
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Anti-proliferative and anti-invasive effects of exogenous thermostable MnSOD in gastric cancer associated with p53 and ZEB1 expression
Hailong Li, Hao Wang, Zong Li, Natalia Kelley, Matt Ouyang, Jia-Wei Wu, Fanguo Meng, Wen-Bin Ou
J. Cancer 2025; 16(6): 2062-2074. doi:10.7150/jca.102600
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Reviews

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Oncolytic Virus Therapy in a New Era of Immunotherapy, Enhanced by Combination with Existing Anticancer Therapies: Turn up the Heat!
Emily Charlotte Fretwell, Annwyne Houldsworth
J. Cancer 2025; 16(6): 1782-1793. doi:10.7150/jca.102285
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Sleep health: an unappreciated key player in colorectal cancer
Jiahua Liu, Qihang Yuan, Yao Zhang, Xinyu Wang, Lijun Zhai, Ruiqi Wang, Chunyu Zheng, Zhijun Hong
J. Cancer 2025; 16(6): 1934-1943. doi:10.7150/jca.107117
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Research progress on molecular mechanism of liver metastasis of gastric cancer and treatment with traditional Chinese medicine
Caiyue Liu, Zheng Li, Fane Cheng, Weiqiang Li, Tingting Li
J. Cancer 2025; 16(6): 1944-1957. doi:10.7150/jca.105223
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Commentary

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Drugging the tumor microenvironment epigenome for therapeutic interventions in NSCLC
Kostas A. Papavassiliou, Amalia A. Sofianidi, Vassiliki A. Gogou, Athanasios G. Papavassiliou
J. Cancer 2025; 16(6): 1832-1835. doi:10.7150/jca.111023
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